Of note: Prometheus was shown at a later date in ENT in the scene aboard the Enterprise J. It was shown to be in service (along with a Dauntless-class and, randomly, a nova class.) during the 26th century Battle of Procyon V. I would LOVE to see a Prometheus or Dauntless class, non-prototype, in the mix.
If we did a Prometheus, it doesn't need MVAM. HOWEVER, I will point out that it gives flight a lot more to do (something we often lack) as well as potentially gives more authority to the XO and second officer as they could each command part.
And I still vehemently oppose a nova/rhode island. Please see the early pages as to why (wrote several posts on it). Short version, "Not big enough to be a 'big ship', not small enough to be a 'small ship', and it doesn't have anything unique about it to split the difference." If others want it however- I am just one voice.